Structural Features of the Interleukin-10 Family of Cytokines
نویسندگان
چکیده
منابع مشابه
Structural features of the interleukin-10 family of cytokines.
The interleukin-10 (IL-10) family of cytokines includes IL-10, a number of its viral gene homologs, and eight recently discovered cellular cytokines (IL-19, IL-20, IL-22, IL-24, IL-26, IFN-lambda1, IFN-lambda2, IFN-lambda3). IL-10 is an intercalated dimer consisting of two six-helix bundle domains. Signal transduction occurs when each domain of IL-10 binds to two receptor chains, IL-10R1 and IL...
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15 صفحه اولStructural analysis of cytokines comprising the IL-10 family.
Interleukin-10 (IL-10) family of cytokines includes a number of its viral homologs and eight cellular cytokines (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29). The latter three proteins are also known as IFN-λ2, IFN-λ3, and IFN-λ1, and are recognized as type III (or λ) interferons. Most of the cellular homologs of IL-10 are monomeric in solution, whereas IL-10 and its viral homo...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2004
ISSN: 1381-6128
DOI: 10.2174/1381612043382602